GRADUATE SCHOOL
M.SC. in Bioengineering (With Thesis)
BEN 513 | Course Introduction and Application Information
Course Name |
Molecular Basis of Gene Therapy
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
BEN 513
|
Fall/Spring
|
3
|
0
|
3
|
7.5
|
Prerequisites |
None
|
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Course Language |
English
|
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Course Type |
Elective
|
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Course Level |
Second Cycle
|
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Mode of Delivery | - | |||||
Teaching Methods and Techniques of the Course | - | |||||
Course Coordinator | ||||||
Course Lecturer(s) | ||||||
Assistant(s) | - |
Course Objectives | The objective of this course is to introduce students molecular basis of cell gene therapy; viral and nonviral gene transfer techniques and gene therapy applications in hereditary and acquired diseases. |
Learning Outcomes |
The students who succeeded in this course;
|
Course Description | This course covers genetic diseases, gene therapy and molecular diagnostics. |
|
Core Courses | |
Major Area Courses |
X
|
|
Supportive Courses | ||
Media and Management Skills Courses | ||
Transferable Skill Courses |
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
Week | Subjects | Related Preparation |
1 | Introduction to Gene Therapy | A Handbook of Gene and Cell Therapy - Chapter 1 |
2 | Non-viral Vectors for Gene Therapy | A Handbook of Gene and Cell Therapy - Chapter 2 |
3 | Viral Vectors for Gene Therapy-1 | A Handbook of Gene and Cell Therapy - Chapter 3 |
4 | Viral Vectors for Gene Therapy-2 | A Handbook of Gene and Cell Therapy - Chapter 3 |
5 | Barriers to Gene Delivery | A Handbook of Gene and Cell Therapy - Chapter 4 |
6 | Stem Cells and Tissue Regeneration-1 | A Handbook of Gene and Cell Therapy - Chapter 5 |
7 | Midterm | |
8 | Stem Cells and Tissue Regeneration-2 | A Handbook of Gene and Cell Therapy - Chapter 5 |
9 | Gene Therapy Strategies: Gene Augmentation | A Handbook of Gene and Cell Therapy - Chapter 6 |
10 | Gene Therapy Strategies: Gene Silencing | A Handbook of Gene and Cell Therapy - Chapter 7 |
11 | Gene Editing | A Handbook of Gene and Cell Therapy - Chapter 8 |
12 | Gene Therapy Applications: Preclinical Studies and Clinical Trials | A Handbook of Gene and Cell Therapy - Chapter 9 |
13 | Gene therapy clinical trials | A Handbook of Gene and Cell Therapy - Chapter 9 |
14 | Gene Therapy for Eye Conditions and Cardiovascular Diseases (CVDs) | A Handbook of Gene and Cell Therapy - Chapter 9 |
15 | Gene Therapy for Neurodegenerative Diseases | A Handbook of Gene and Cell Therapy - Chapter 9 |
16 | Final Exam |
Course Notes/Textbooks | An Introduction to Human Molecular Genetics (2nd Edition), J.J. Pasternak, 2005 An Introduction to Molecular Medicine and Gene Therapy 1st Edition by Thomas F. Kresina A Handbook of Gene and Cell Therapy. Authors: Nobrega, Clevio, Mendonça, Liliana, Matos, Carlos. ISBN 978-3-030-41333-0. 2020. |
Suggested Readings/Materials | Human Molecular Genetics (4th Edition), Tom Strachan & Andrew Read, 2010. A Handbook of Gene and Cell Therapy. Authors: Nobrega, Clevio, Mendonça, Liliana, Matos, Carlos. ISBN 978-3-030-41333-0. 2020. |
EVALUATION SYSTEM
Semester Activities | Number | Weigthing |
Participation | ||
Laboratory / Application | ||
Field Work | ||
Quizzes / Studio Critiques |
1
|
10
|
Portfolio | ||
Homework / Assignments |
1
|
20
|
Presentation / Jury |
1
|
20
|
Project | ||
Seminar / Workshop | ||
Oral Exams | ||
Midterm |
1
|
20
|
Final Exam |
1
|
30
|
Total |
Weighting of Semester Activities on the Final Grade |
4
|
70
|
Weighting of End-of-Semester Activities on the Final Grade |
1
|
30
|
Total |
ECTS / WORKLOAD TABLE
Semester Activities | Number | Duration (Hours) | Workload |
---|---|---|---|
Theoretical Course Hours (Including exam week: 16 x total hours) |
16
|
3
|
48
|
Laboratory / Application Hours (Including exam week: '.16.' x total hours) |
16
|
0
|
|
Study Hours Out of Class |
15
|
3
|
45
|
Field Work |
0
|
||
Quizzes / Studio Critiques |
1
|
4
|
4
|
Portfolio |
0
|
||
Homework / Assignments |
1
|
4
|
4
|
Presentation / Jury |
1
|
6
|
6
|
Project |
0
|
||
Seminar / Workshop |
0
|
||
Oral Exam |
0
|
||
Midterms |
1
|
30
|
30
|
Final Exam |
1
|
50
|
50
|
Total |
187
|
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
#
|
Program Competencies/Outcomes |
* Contribution Level
|
||||
1
|
2
|
3
|
4
|
5
|
||
1 | To be able to have adequate knowledge in Mathematics, Life Sciences and Bioengineering; to be able to use theoretical and applied information in these areas to model and solve Bioengineering problems. |
|||||
2 | To be able to use scientific methods to complete and apply information from uncertain, limited or incomplete data; to be able to combine and use information from related disciplines. |
X | ||||
3 | To be able to design and apply theoretical, experimental and model-based research; to be able to solve complex problems in such processes. |
|||||
4 | Being able to utilize Natural Sciences and Bioengineering principles to design systems, devices and processes. |
X | ||||
5 | To be able to follow and apply new developments and technologies in the field of Bioengineering. |
X | ||||
6 | To be able to work effectively in multi-disciplinary teams within the discipline of Bioengineering; to be able to exhibit individual work. |
X | ||||
7 | To be able to have the knowledge about the social, environmental, health, security and law implications of Bioengineering applications, to be able to have the knowledge to manage projects and business applications, and to be able to be aware of their limitations in professional life. |
X | ||||
8 | To be able to have the social, scientific and ethical values in the stages of collection, interpretation, dissemination and application of data related to the field of Bioengineering. |
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9 | To be able to prepare an original thesis/term project in accordance with the criteria related to the field of Bioengineering. |
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10 | To be able to follow information about Bioengineering in a foreign language and to be able to participate in discussions in academic environments. |
X | ||||
11 | To be able to improve the acquired knowledge, skills and qualifications for social and universal purposes regarding the studied area. |
|||||
12 | To be able to recognize regional and global issues/problems, and to be able to develop solutions based on research and scientific evidence related to Bioengineering. |
X |
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest