GRADUATE SCHOOL
M.SC. in Bioengineering (With Thesis)
BEN 514 | Course Introduction and Application Information
| Course Name |
Epigenetic Bases of Human Diseases
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
BEN 514
|
Fall/Spring
|
3
|
0
|
3
|
7.5
|
| Prerequisites |
None
|
|||||
| Course Language |
English
|
|||||
| Course Type |
Elective
|
|||||
| Course Level |
Second Cycle
|
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| Mode of Delivery | - | |||||
| Teaching Methods and Techniques of the Course | - | |||||
| Course Coordinator | ||||||
| Course Lecturer(s) | ||||||
| Assistant(s) | - | |||||
| Course Objectives | The objective of this course is to learn the function and organisation of epigenome (e.g. DNA and histone modifications and non-coding RNAs... etc) and understanding the importance of epigenetic variations in human health and disease. |
| Learning Outcomes |
The students who succeeded in this course;
|
| Course Description |
|
|
Core Courses | |
| Major Area Courses |
X
|
|
| Supportive Courses | ||
| Media and Management Skills Courses | ||
| Transferable Skill Courses |
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Related Preparation |
| 1 | Brief History of Epigenetics and General Concepts | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapters 1, 2 and 3. |
| 2 | Packaging of DNA and chromatin | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapters 1,2 and 3. |
| 3 | DNA modifications | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapter 15. |
| 4 | Histone modifications: Acetylation | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapter 4. |
| 5 | Histone modifications: Methylation and others | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapter 5. |
| 6 | Gene control regions and epigenetics | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapters 12 and 19. |
| 7 | Non-coding RNAs and epigenetics | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapter 16. |
| 8 | Review for Midterm | |
| 9 | Epigenetics of Neurological Diseases | Epigenetics in Human Disease 2nd edition, T Tollefsbol, Elsevier Academic Press, 2018. Chapters 8 and 9. |
| 10 | Epigenetics of Immune Diseases | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapter 29. |
| 11 | Epigenetics of Metabolic Diseases | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapter 30. |
| 12 | Epigenetic changes induced by infections | Epigenetics in Human Disease 2nd edition, T Tollefsbol, Elsevier Academic Press, 2018. Chapter 21. |
| 13 | Epigenetics and Aging | Epigenetics in Human Disease 2nd edition, T Tollefsbol, Elsevier Academic Press, 2018. Chapter 31. |
| 14 | Epigenetic Mechanisms in Cancer | Epigenetics, 2nd edition, by D Allis, CSHL Press, 2015. Chapters 34 and 35. |
| 15 | Review of Semester | |
| 16 | Final Exam |
| Course Notes/Textbooks | Epigenetics, 2nd edition, by D Allis, Cold Spring Harbor Laboratory Press, 2015 |
| Suggested Readings/Materials | Epigenetics in Human Disease 2nd edition, T Tollefsbol, Elsevier Academic Press, 2018 |
EVALUATION SYSTEM
| Semester Activities | Number | Weigthing |
| Participation | ||
| Laboratory / Application | ||
| Field Work | ||
| Quizzes / Studio Critiques | ||
| Portfolio | ||
| Homework / Assignments |
1
|
10
|
| Presentation / Jury |
1
|
15
|
| Project | ||
| Seminar / Workshop | ||
| Oral Exams | ||
| Midterm |
1
|
35
|
| Final Exam |
1
|
40
|
| Total |
| Weighting of Semester Activities on the Final Grade |
3
|
60
|
| Weighting of End-of-Semester Activities on the Final Grade |
1
|
40
|
| Total |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Theoretical Course Hours (Including exam week: 16 x total hours) |
16
|
3
|
48
|
| Laboratory / Application Hours (Including exam week: '.16.' x total hours) |
16
|
0
|
|
| Study Hours Out of Class |
16
|
4
|
64
|
| Field Work |
0
|
||
| Quizzes / Studio Critiques |
0
|
||
| Portfolio |
0
|
||
| Homework / Assignments |
1
|
20
|
20
|
| Presentation / Jury |
1
|
20
|
20
|
| Project |
0
|
||
| Seminar / Workshop |
0
|
||
| Oral Exam |
0
|
||
| Midterms |
1
|
33
|
33
|
| Final Exam |
1
|
40
|
40
|
| Total |
225
|
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
|
#
|
Program Competencies/Outcomes |
* Contribution Level
|
||||
|
1
|
2
|
3
|
4
|
5
|
||
| 1 | To be able to have adequate knowledge in Mathematics, Life Sciences and Bioengineering; to be able to use theoretical and applied information in these areas to model and solve Bioengineering problems. |
X | ||||
| 2 | To be able to use scientific methods to complete and apply information from uncertain, limited or incomplete data; to be able to combine and use information from related disciplines. |
X | ||||
| 3 | To be able to design and apply theoretical, experimental and model-based research; to be able to solve complex problems in such processes. |
X | ||||
| 4 | Being able to utilize Natural Sciences and Bioengineering principles to design systems, devices and processes. |
X | ||||
| 5 | To be able to follow and apply new developments and technologies in the field of Bioengineering. |
X | ||||
| 6 | To be able to work effectively in multi-disciplinary teams within the discipline of Bioengineering; to be able to exhibit individual work. |
X | ||||
| 7 | To be able to have the knowledge about the social, environmental, health, security and law implications of Bioengineering applications, to be able to have the knowledge to manage projects and business applications, and to be able to be aware of their limitations in professional life. |
X | ||||
| 8 | To be able to have the social, scientific and ethical values in the stages of collection, interpretation, dissemination and application of data related to the field of Bioengineering. |
X | ||||
| 9 | To be able to prepare an original thesis/term project in accordance with the criteria related to the field of Bioengineering. |
|||||
| 10 | To be able to follow information about Bioengineering in a foreign language and to be able to participate in discussions in academic environments. |
X | ||||
| 11 | To be able to improve the acquired knowledge, skills and qualifications for social and universal purposes regarding the studied area. |
X | ||||
| 12 | To be able to recognize regional and global issues/problems, and to be able to develop solutions based on research and scientific evidence related to Bioengineering. |
X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest