GRADUATE SCHOOL
M.SC. in Bioengineering (With Thesis)
BEN 516 | Course Introduction and Application Information
| Course Name |
Protein Structure, Function and Engineering
|
|
Code
|
Semester
|
Theory
(hour/week) |
Application/Lab
(hour/week) |
Local Credits
|
ECTS
|
|
BEN 516
|
Fall/Spring
|
3
|
0
|
3
|
7.5
|
| Prerequisites |
None
|
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| Course Language |
English
|
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| Course Type |
Elective
|
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| Course Level |
Second Cycle
|
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| Mode of Delivery | - | |||||
| Teaching Methods and Techniques of the Course | - | |||||
| Course Coordinator | ||||||
| Course Lecturer(s) | ||||||
| Assistant(s) | - | |||||
| Course Objectives | The aim is to explain the genetic, biochemical and chemical techniques to understand protein biochemistry and structure, protein production and characterization. During the semester we will discuss protein folding, enzymes’ mechanism of action, protein engineering tools and technologies. In addition, we will explain examples of designed proteins in medicine, nanobiotechnology. |
| Learning Outcomes |
The students who succeeded in this course;
|
| Course Description |
|
|
Core Courses | |
| Major Area Courses |
X
|
|
| Supportive Courses | ||
| Media and Management Skills Courses | ||
| Transferable Skill Courses |
WEEKLY SUBJECTS AND RELATED PREPARATION STUDIES
| Week | Subjects | Related Preparation |
| 1 | Introduction, Amino Acids | Lecture notes |
| 2 | Proteins: Primary Structure | Lecture notes |
| 3 | Proteins: 3-Dimensional Structure | Lecture notes |
| 4 | Functions of proteins | Lecture notes |
| 5 | Enzymatic catalysis | Lecture notes |
| 6 | Recombinant DNA technology | Lecture notes |
| 7 | Protein production and isolation | Lecture notes |
| 8 | Protein Characterization | Lecture notes |
| 9 | Midterm | Lecture notes |
| 10 | Protein folding and stability | Lecture notes |
| 11 | Enzyme Kinetics and mechanism | Lecture notes |
| 12 | Enzyme inactivation | Lecture notes and articles |
| 13 | Protein Engineering methods: Rational Protein Design | Lecture notes and articles |
| 14 | Protein Engineering methods: Directed Evolution Methods | Lecture notes and articles |
| 15 | Student Seminars | |
| 16 | Final Exam |
| Course Notes/Textbooks | Lecture notes and scientific recent articles http://www.ncbi.nlm.nih.gov/pubmed Fundamentals of Protein Structure and Function by Engelbert Buxbaum Springer; 2nd ed. 2015 edition |
| Suggested Readings/Materials |
|
EVALUATION SYSTEM
| Semester Activities | Number | Weigthing |
| Participation |
1
|
10
|
| Laboratory / Application | ||
| Field Work | ||
| Quizzes / Studio Critiques | ||
| Portfolio | ||
| Homework / Assignments | ||
| Presentation / Jury |
1
|
10
|
| Project |
1
|
15
|
| Seminar / Workshop | ||
| Oral Exams | ||
| Midterm |
1
|
30
|
| Final Exam |
1
|
35
|
| Total |
| Weighting of Semester Activities on the Final Grade |
3
|
65
|
| Weighting of End-of-Semester Activities on the Final Grade |
1
|
35
|
| Total |
ECTS / WORKLOAD TABLE
| Semester Activities | Number | Duration (Hours) | Workload |
|---|---|---|---|
| Theoretical Course Hours (Including exam week: 16 x total hours) |
16
|
3
|
48
|
| Laboratory / Application Hours (Including exam week: '.16.' x total hours) |
16
|
0
|
|
| Study Hours Out of Class |
15
|
3
|
45
|
| Field Work |
0
|
||
| Quizzes / Studio Critiques |
0
|
||
| Portfolio |
0
|
||
| Homework / Assignments |
0
|
||
| Presentation / Jury |
1
|
10
|
10
|
| Project |
1
|
20
|
20
|
| Seminar / Workshop |
0
|
||
| Oral Exam |
0
|
||
| Midterms |
1
|
25
|
25
|
| Final Exam |
1
|
30
|
30
|
| Total |
178
|
COURSE LEARNING OUTCOMES AND PROGRAM QUALIFICATIONS RELATIONSHIP
|
#
|
Program Competencies/Outcomes |
* Contribution Level
|
||||
|
1
|
2
|
3
|
4
|
5
|
||
| 1 | To be able to have adequate knowledge in Mathematics, Life Sciences and Bioengineering; to be able to use theoretical and applied information in these areas to model and solve Bioengineering problems. |
X | ||||
| 2 | To be able to use scientific methods to complete and apply information from uncertain, limited or incomplete data; to be able to combine and use information from related disciplines. |
X | ||||
| 3 | To be able to design and apply theoretical, experimental and model-based research; to be able to solve complex problems in such processes. |
X | ||||
| 4 | Being able to utilize Natural Sciences and Bioengineering principles to design systems, devices and processes. |
X | ||||
| 5 | To be able to follow and apply new developments and technologies in the field of Bioengineering. |
X | ||||
| 6 | To be able to work effectively in multi-disciplinary teams within the discipline of Bioengineering; to be able to exhibit individual work. |
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| 7 | To be able to have the knowledge about the social, environmental, health, security and law implications of Bioengineering applications, to be able to have the knowledge to manage projects and business applications, and to be able to be aware of their limitations in professional life. |
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| 8 | To be able to have the social, scientific and ethical values in the stages of collection, interpretation, dissemination and application of data related to the field of Bioengineering. |
|||||
| 9 | To be able to prepare an original thesis/term project in accordance with the criteria related to the field of Bioengineering. |
|||||
| 10 | To be able to follow information about Bioengineering in a foreign language and to be able to participate in discussions in academic environments. |
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| 11 | To be able to improve the acquired knowledge, skills and qualifications for social and universal purposes regarding the studied area. |
X | ||||
| 12 | To be able to recognize regional and global issues/problems, and to be able to develop solutions based on research and scientific evidence related to Bioengineering. |
X | ||||
*1 Lowest, 2 Low, 3 Average, 4 High, 5 Highest